दवाओं की अंतःक्रिया
Exemestane + Mitotane
गंभीरता: गंभीर
Exemestane and Mitotane: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Mitotane is a strong CYP3A4 inducer that persists for weeks after discontinuation and can substantially lower exemestane concentrations. Reduced exposure may compromise the antiestrogenic effect of treatment.
इस इंटरैक्शन का सरल भाषा में अर्थ
Exemestane and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Exemestane belongs to Oncology; Mitotane belongs to Oncology.
ऐसा क्यों होता है
Mitotane induces CYP3A4, accelerating the metabolism of exemestane.
क्या करें
Increase exemestane to 50 mg daily after a meal when a strong CYP3A4 inducer is co-administered, and monitor treatment response. Consider that the induction continues after mitotane is stopped.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Exemestane और Mitotane की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Exemestane के अन्य इंटरैक्शन
Mitotane के अन्य इंटरैक्शन
- Doravirine + Mitotane निषिद्ध
- Fostemsavir + Mitotane निषिद्ध
- Lorlatinib + Mitotane निषिद्ध
- Abiraterone + Mitotane गंभीर
- Apixaban + Mitotane गंभीर
- Aprepitant + Mitotane गंभीर
अक्सर पूछे जाने वाले प्रश्न
Can I take Exemestane with Mitotane?
MediHelp rates the interaction as major. Exemestane and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mitotane is a strong CYP3A4 inducer that persists for weeks after discontinuation and can substantially lower exemestane concentrations. Reduced exposure may compromise the antiestrogenic effect of treatment.
How serious is the interaction between Exemestane and Mitotane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase exemestane to 50 mg daily after a meal when a strong CYP3A4 inducer is co-administered, and monitor treatment response. Consider that the induction continues after mitotane is stopped.
What other medicines interact with Exemestane?
MediHelp also lists interactions of Exemestane with, for example, Bazedoxifene-conjugated estrogens, Desogestrel-ethinyl estradiol, Estradiol. The full list is on the Exemestane page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
