दवाओं की अंतःक्रिया
Fluvastatin + Gemfibrozil
गंभीरता: गंभीर
Fluvastatin and Gemfibrozil: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Gemfibrozil inhibits OATP1B1 and glucuronidation and fibrates also have intrinsic myotoxicity, which can raise statin exposure. Fluvastatin is mainly cleared by CYP2C9, so the pharmacokinetic rise is smaller than for other statins, but myopathy and rhabdomyolysis remain possible.
इस इंटरैक्शन का सरल भाषा में अर्थ
Fluvastatin and Gemfibrozil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluvastatin belongs to Cardiovascular; Gemfibrozil belongs to Cardiovascular.
ऐसा क्यों होता है
Additive myotoxicity with possible OATP1B1 inhibition
क्या करें
Avoid where possible; if both are needed use the lowest fluvastatin dose, and advise patients to report muscle pain or dark urine; check CK if symptomatic.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Fluvastatin और Gemfibrozil की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Fluvastatin के अन्य इंटरैक्शन
Gemfibrozil के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Fluvastatin with Gemfibrozil?
MediHelp rates the interaction as major. Fluvastatin and Gemfibrozil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gemfibrozil inhibits OATP1B1 and glucuronidation and fibrates also have intrinsic myotoxicity, which can raise statin exposure. Fluvastatin is mainly cleared by CYP2C9, so the pharmacokinetic rise is smaller than for other statins, but myopathy and rhabdomyolysis remain possible.
How serious is the interaction between Fluvastatin and Gemfibrozil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible; if both are needed use the lowest fluvastatin dose, and advise patients to report muscle pain or dark urine; check CK if symptomatic.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Letermovir. The full list is on the Fluvastatin page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
