दवाओं की अंतःक्रिया
Gemfibrozil + Metformin-pioglitazone
गंभीरता: गंभीर
Gemfibrozil and Metformin-pioglitazone: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Gemfibrozil substantially increases pioglitazone exposure by inhibiting its metabolism. This raises the risk of dose-related adverse effects such as edema, weight gain, heart failure and hypoglycemia.
इस इंटरैक्शन का सरल भाषा में अर्थ
Gemfibrozil and Metformin-pioglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gemfibrozil belongs to Cardiovascular; Metformin-pioglitazone belongs to Endocrine.
ऐसा क्यों होता है
Gemfibrozil inhibits CYP2C8, the main enzyme metabolizing pioglitazone.
क्या करें
Limit pioglitazone to a maximum of 15 mg daily with gemfibrozil. Monitor glucose and for edema or heart failure signs.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Gemfibrozil और Metformin-pioglitazone की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Metformin-pioglitazone के अन्य इंटरैक्शन
Gemfibrozil के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Gemfibrozil with Metformin-pioglitazone?
MediHelp rates the interaction as major. Gemfibrozil and Metformin-pioglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gemfibrozil substantially increases pioglitazone exposure by inhibiting its metabolism. This raises the risk of dose-related adverse effects such as edema, weight gain, heart failure and hypoglycemia.
How serious is the interaction between Gemfibrozil and Metformin-pioglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit pioglitazone to a maximum of 15 mg daily with gemfibrozil. Monitor glucose and for edema or heart failure signs.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
