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दवाओं की अंतःक्रिया

Isocarboxazid + Methadone

गंभीरता: निषिद्ध

Isocarboxazid and Methadone: contraindicated interaction.

अंतिम अपडेट

केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।

इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।

सारांश

Combining methadone with a nonselective MAO inhibitor risks serotonin toxicity, hypotension, hyperthermia, marked sedation and respiratory depression. Methadone's labeling warns against use with MAOIs or within 14 days of stopping one.

इस इंटरैक्शन का सरल भाषा में अर्थ

Isocarboxazid and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Isocarboxazid belongs to Central Nervous System; Methadone belongs to Musculoskeletal.

साक्ष्य स्तर: Moderate

ऐसा क्यों होता है

MAO inhibition combined with methadone's serotonergic activity may precipitate serotonin syndrome, plus additive CNS depression.

क्या करें

Do not use together or within 14 days of stopping the MAOI. Use a non-serotonergic analgesic or opioid-treatment alternative.

फार्मासिस्ट से क्या पूछें

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ सदस्यों के लिए

पूरा पेज खोलें

Isocarboxazid और Methadone की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।

अक्सर पूछे जाने वाले प्रश्न

Can I take Isocarboxazid with Methadone?

MediHelp rates the interaction as contraindicated. Isocarboxazid and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining methadone with a nonselective MAO inhibitor risks serotonin toxicity, hypotension, hyperthermia, marked sedation and respiratory depression. Methadone's labeling warns against use with MAOIs or within 14 days of stopping one.

How serious is the interaction between Isocarboxazid and Methadone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together or within 14 days of stopping the MAOI. Use a non-serotonergic analgesic or opioid-treatment alternative.

What other medicines interact with Methadone?

MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.

MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर

MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।

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