दवाओं की अंतःक्रिया
Isosorbide mononitrate + Tadalafil
गंभीरता: निषिद्ध
Isosorbide mononitrate and Tadalafil: contraindicated interaction.
अंतिम अपडेट स्रोत: US FDA label
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Tadalafil markedly potentiates the hypotensive effect of nitrates, which can cause severe, potentially life-threatening hypotension, syncope or myocardial ischaemia. The effect persists for a prolonged period because of tadalafil's long half-life. Nitrates in any form are contraindicated with tadalafil.
इस इंटरैक्शन का सरल भाषा में अर्थ
Isosorbide mononitrate and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isosorbide mononitrate belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
ऐसा क्यों होता है
Nitrates increase cGMP by nitric oxide release while tadalafil inhibits PDE5-mediated cGMP breakdown, causing excessive vasodilation.
क्या करें
Do not coadminister. Nitrates should not be given within at least 48 hours after tadalafil, and in emergencies the decision should be under close medical supervision.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Isosorbide mononitrate और Tadalafil की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
संदर्भ
- Cialis (tadalafil) Prescribing Information - Contraindications — FDA Label
- Cialis SmPC - Contraindications — EMA SmPC
Tadalafil के अन्य इंटरैक्शन
- Amyl nitrite + Tadalafil निषिद्ध
- Isosorbide dinitrate + Tadalafil निषिद्ध
- Nitroglycerin po + Tadalafil निषिद्ध
- Nitroglycerin rectal + Tadalafil निषिद्ध
- Nitroglycerin sublingual + Tadalafil निषिद्ध
- Nitroglycerin transdermal + Tadalafil निषिद्ध
Isosorbide mononitrate के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Isosorbide mononitrate with Tadalafil?
MediHelp rates the interaction as contraindicated. Isosorbide mononitrate and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tadalafil markedly potentiates the hypotensive effect of nitrates, which can cause severe, potentially life-threatening hypotension, syncope or myocardial ischaemia. The effect persists for a prolonged period because of tadalafil's long half-life. Nitrates in any form are contraindicated with tadalafil.
How serious is the interaction between Isosorbide mononitrate and Tadalafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Nitrates should not be given within at least 48 hours after tadalafil, and in emergencies the decision should be under close medical supervision.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Nitroglycerin po. The full list is on the Tadalafil page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
