दवाओं की अंतःक्रिया
Itraconazole + Venetoclax
गंभीरता: निषिद्ध
Itraconazole and Venetoclax: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Itraconazole increases venetoclax exposure and risks tumor lysis syndrome during dose initiation, as well as neutropenia and other toxicities. The risk is greatest during the ramp-up phase.
इस इंटरैक्शन का सरल भाषा में अर्थ
Itraconazole and Venetoclax are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Itraconazole belongs to Anti Fungals; Venetoclax belongs to Miscellaneous.
ऐसा क्यों होता है
Strong CYP3A4 inhibition (and P-glycoprotein inhibition) by itraconazole reduces venetoclax clearance.
क्या करें
Do not use during venetoclax initiation and ramp-up; after ramp-up, reduce the venetoclax dose by at least 75% per labeling and monitor for toxicity and blood counts.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Itraconazole और Venetoclax की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 7 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Itraconazole के अन्य इंटरैक्शन
- Alfuzosin + Itraconazole निषिद्ध
- Alprazolam + Itraconazole निषिद्ध
- Avanafil + Itraconazole निषिद्ध
- Conivaptan + Itraconazole निषिद्ध
- Dihydroergotamine intranasal + Itraconazole निषिद्ध
- Dihydroergotamine + Itraconazole निषिद्ध
Venetoclax के अन्य इंटरैक्शन
- Clarithromycin + Venetoclax निषिद्ध
- Ketoconazole + Venetoclax निषिद्ध
- Posaconazole + Venetoclax निषिद्ध
- Venetoclax + Voriconazole निषिद्ध
- Amiodarone + Venetoclax गंभीर
- Apalutamide + Venetoclax गंभीर
अक्सर पूछे जाने वाले प्रश्न
Can I take Itraconazole with Venetoclax?
MediHelp rates the interaction as contraindicated. Itraconazole and Venetoclax are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole increases venetoclax exposure and risks tumor lysis syndrome during dose initiation, as well as neutropenia and other toxicities. The risk is greatest during the ramp-up phase.
How serious is the interaction between Itraconazole and Venetoclax?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use during venetoclax initiation and ramp-up; after ramp-up, reduce the venetoclax dose by at least 75% per labeling and monitor for toxicity and blood counts.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
