दवाओं की अंतःक्रिया
Pentostatin + Tofacitinib
गंभीरता: गंभीर
Pentostatin and Tofacitinib: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Pentostatin causes profound lymphocyte depletion and immunosuppression, so combining it with tofacitinib increases the risk of severe and opportunistic infections. Pentostatin also has other toxicities such as renal and neurologic effects.
इस इंटरैक्शन का सरल भाषा में अर्थ
Pentostatin and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pentostatin belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
ऐसा क्यों होता है
Additive immunosuppression from JAK inhibition and adenosine deaminase inhibition causing lymphocyte toxicity.
क्या करें
Avoid concurrent use and consider holding tofacitinib during pentostatin therapy. If both are needed, monitor for infection and consider prophylaxis.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Pentostatin और Tofacitinib की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Tofacitinib के अन्य इंटरैक्शन
Pentostatin के अन्य इंटरैक्शन
- Carmustine + Pentostatin निषिद्ध
- Etoposide + Pentostatin निषिद्ध
- Fludarabine + Pentostatin निषिद्ध
- Cyclophosphamide + Pentostatin गंभीर
- Deferiprone + Pentostatin गंभीर
- Fingolimod + Pentostatin गंभीर
अक्सर पूछे जाने वाले प्रश्न
Can I take Pentostatin with Tofacitinib?
MediHelp rates the interaction as major. Pentostatin and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pentostatin causes profound lymphocyte depletion and immunosuppression, so combining it with tofacitinib increases the risk of severe and opportunistic infections. Pentostatin also has other toxicities such as renal and neurologic effects.
How serious is the interaction between Pentostatin and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and consider holding tofacitinib during pentostatin therapy. If both are needed, monitor for infection and consider prophylaxis.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
