दवाओं की अंतःक्रिया
Rifampin + Roflumilast
गंभीरता: गंभीर
Rifampin and Roflumilast: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Rifampicin markedly lowers roflumilast and active metabolite exposure, and the label advises against use with strong inducers. Loss of therapeutic effect is likely.
इस इंटरैक्शन का सरल भाषा में अर्थ
Rifampin and Roflumilast can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
ऐसा क्यों होता है
Rifampicin strongly induces CYP3A4 and CYP1A2, increasing roflumilast clearance.
क्या करें
Avoid concurrent use; if rifampicin is required, use an alternative COPD therapy for the duration. Induction persists for some weeks after stopping.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Rifampin और Roflumilast की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 7 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Roflumilast के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Rifampin with Roflumilast?
MediHelp rates the interaction as major. Rifampin and Roflumilast can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin markedly lowers roflumilast and active metabolite exposure, and the label advises against use with strong inducers. Loss of therapeutic effect is likely.
How serious is the interaction between Rifampin and Roflumilast?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; if rifampicin is required, use an alternative COPD therapy for the duration. Induction persists for some weeks after stopping.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
