Справочник лекарств
Methohexital
Methohexital is a medicine in the class central nervous system. It is used for general anesthesia.
- Класс препарата: Central Nervous System
- Показания: general anesthesia
Последнее обновление Источники: US FDA label
Для специалистов здравоохранения — только для справки. Эта страница — краткая сводка, а не медицинская консультация и не замена официальной инструкции или клинического суждения. Всегда проверяйте перед назначением или отпуском.
Клиническое содержание этой страницы доступно только на английском языке.
Главное
- Класс препарата
- Central Nervous System
- Частые лекарственные формы
- инъекция
- Частые дозировки
- 500 mg
- Известные взаимодействия
- 118 (Тяжёлое: 27 · Умеренное: 83 · Незначительное: 8)
- Торговые названия
- 1
- Страны и рынки
- 1
Для чего применяется
Как действует
Methohexital is a sulfur-free barbiturate anesthetic. After intravenous administration it is rapidly taken up by the brain (within 30 seconds) and rapidly induces sleep. With single doses, the rate of redistribution determines the duration of effect. It provides little analgesia.
Обычная доза для взрослых (кратко по инструкции)
Induction of anesthesia: 1% solution IV at about 1 mL/5 seconds; usual dose 1 to 1.5 mg/kg (range 50 to 120 mg or more, averages about 70 mg); provides anesthesia for 5 to 7 minutes
Беременность и грудное вскармливание
- Беременность
- Unknown No adequate human studies; no developmental effects in rats and rabbits. FDA warns that lengthy or repeated general anaesthesia in the 3rd trimester may affect the developing brain (animal data). Use for needed anaesthesia or ECT at the usual dose.
- Грудное вскармливание
- Safe Amounts in milk are very small. US label: use with caution. LactMed: no waiting period is needed after a single dose; breastfeed as soon as the mother is alert enough. When several anaesthetic drugs are used, follow the most restrictive one.
Зарегистрированные побочные эффекты
- Hypotension
- Tachycardia
- Respiratory depression including apnea
- Laryngospasm
- Hiccups
- Skeletal muscle twitching
Предупреждения в рамке
- Use only in hospital or ambulatory care settings with continuous monitoring of respiratory and cardiac function. Resuscitative drugs, age- and size-appropriate airway equipment and trained personnel must be immediately available. Deeply sedated patients need a designated individual other than the proceduralist to monitor continuously.
Противопоказания
- Patients in whom general anesthesia is contraindicated
- Latent or manifest porphyria
- Known hypersensitivity to barbiturates
Кому следует соблюдать осторожность
- Laryngospasm, apnea/hypoventilation and cardiorespiratory arrest may occur; maintain airway and ventilation
- Seizures may be elicited in patients with a history of convulsive activity, especially partial seizure disorders
- Unintended intra-arterial injection may cause thrombosis, necrosis and gangrene; use 1% concentration and confirm venous placement
Сообщите фармацевту или врачу о беременности или грудном вскармливании, заболеваниях почек или печени, аллергии и обо всех других лекарствах и добавках, которые вы принимаете.
Главные взаимодействия (118)
- Alprazolam + Methohexital Major
- Amobarbital + Methohexital Major
- Buprenorphine + Methohexital Major
- Chlordiazepoxide + Methohexital Major
- Chlordiazepoxide-clidinium + Methohexital Major
- Clemastine + Methohexital Major
- Clorazepate + Methohexital Major
- Clozapine + Methohexital Major
- Codeine + Methohexital Major
- Esketamine + Methohexital Major
Для подписчиков Pro+
Откройте страницу целиком
Создайте аккаунт и начните пробный период Pro+, чтобы открыть полную монографию Methohexital: дозы, беременность и грудное вскармливание, побочные эффекты, предупреждения и все взаимодействия.
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
Pro+ бесплатно 14 дней на сайте. Карта не нужна.
Другие препараты этого класса
Частые вопросы
What is Methohexital used for?
Methohexital is a medicine in the class central nervous system. It is used for General anesthesia, General anesthesia adjunct.
What side effects have been reported with Methohexital?
Hypotension, Tachycardia, Respiratory depression including apnea, Laryngospasm, Hiccups, Skeletal muscle twitching. Serious warning: Use only in hospital or ambulatory care settings with continuous monitoring of respiratory and cardiac function.
Can Methohexital be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate human studies; no developmental effects in rats and rabbits. FDA warns that lengthy or repeated general anaesthesia in the 3rd trimester may affect the developing brain (animal data). Use for needed anaesthesia or ECT at the usual dose. Breastfeeding: Safe. Amounts in milk are very small. US label: use with caution. LactMed: no waiting period is needed after a single dose; breastfeed as soon as the mother is alert enough. When several anaesthetic drugs are used, follow the most restrictive one.
What does Methohexital interact with?
MediHelp lists 118 known interactions for Methohexital. Major: 27 · Moderate: 83 · Minor: 8. The most serious include Alprazolam, Amobarbital, Buprenorphine.
Полные монографии, дозировки и проверка взаимодействий в приложении MediHelp
Откройте полный справочник, проверяйте взаимодействия нескольких препаратов и пользуйтесь инструментами дозирования в приложении MediHelp.
