Лекарственные взаимодействия
Allogeneic cultured keratinocytes and fibroblasts + Silver sulfadiazine
Тяжесть: Умеренное
Allogeneic cultured keratinocytes and fibroblasts and Silver sulfadiazine: moderate interaction.
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Кратко
Silver sulfadiazine applied to a wound leaves silver ions that are toxic to living cells. This can reduce the viability of the cultured keratinocytes and fibroblasts in the cell-based skin product and impair graft take.
Что означает это взаимодействие простыми словами
Allogeneic cultured keratinocytes and fibroblasts and Silver sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Почему это происходит
Local cytotoxicity of silver ions toward cultured human keratinocytes and fibroblasts.
Что делать
Do not apply silver sulfadiazine or silver dressings to the site before or at the time of application of the cellular product. Rinse the wound bed thoroughly if silver was previously used.
О чём спросить фармацевта
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Другие взаимодействия Silver sulfadiazine
- Collagenase + Silver sulfadiazine Умеренное
- Papain + Silver sulfadiazine Умеренное
- Silver sulfadiazine + Trypsin Умеренное
Частые вопросы
Can I take Allogeneic cultured keratinocytes and fibroblasts with Silver sulfadiazine?
MediHelp rates the interaction as moderate. Allogeneic cultured keratinocytes and fibroblasts and Silver sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Silver sulfadiazine applied to a wound leaves silver ions that are toxic to living cells. This can reduce the viability of the cultured keratinocytes and fibroblasts in the cell-based skin product and impair graft take.
How serious is the interaction between Allogeneic cultured keratinocytes and fibroblasts and Silver sulfadiazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not apply silver sulfadiazine or silver dressings to the site before or at the time of application of the cellular product. Rinse the wound bed thoroughly if silver was previously used.
What other medicines interact with Silver sulfadiazine?
MediHelp also lists interactions of Silver sulfadiazine with, for example, Collagenase, Papain, Trypsin. The full list is on the Silver sulfadiazine page.
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