Лекарственные взаимодействия
Alvimopan + Morphine
Тяжесть: Противопоказано
Alvimopan and Morphine: contraindicated interaction.
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Кратко
Alvimopan is a peripherally acting mu-opioid antagonist, and patients who have taken opioids for more than a week before starting it are more sensitive to its effects. They may develop abdominal pain, nausea, vomiting and diarrhea. Short-term opioid exposure, as in the postoperative setting, is the intended use.
Что означает это взаимодействие простыми словами
Alvimopan and Morphine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Почему это происходит
Competitive antagonism at peripheral gastrointestinal mu-opioid receptors in opioid-tolerant patients.
Что делать
Do not give alvimopan to patients who have received therapeutic opioid doses for more than 7 consecutive days before it. Limit use to short-term perioperative opioid exposure.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Другие взаимодействия Morphine
- Isocarboxazid + Morphine Противопоказано
- Morphine + Olanzapine / samidorphan Противопоказано
- Morphine + Phenelzine Противопоказано
- Morphine + Tranylcypromine Противопоказано
- Alfentanil + Morphine Тяжёлое
- Alprazolam + Morphine Тяжёлое
Частые вопросы
Can I take Alvimopan with Morphine?
MediHelp rates the interaction as contraindicated. Alvimopan and Morphine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Alvimopan is a peripherally acting mu-opioid antagonist, and patients who have taken opioids for more than a week before starting it are more sensitive to its effects. They may develop abdominal pain, nausea, vomiting and diarrhea. Short-term opioid exposure, as in the postoperative setting, is the intended use.
How serious is the interaction between Alvimopan and Morphine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give alvimopan to patients who have received therapeutic opioid doses for more than 7 consecutive days before it. Limit use to short-term perioperative opioid exposure.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Morphine page.
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