Лекарственные взаимодействия
Benzhydrocodone / acetaminophen + Oxcarbazepine
Тяжесть: Тяжёлое
Benzhydrocodone / acetaminophen and Oxcarbazepine: major interaction.
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Кратко
Oxcarbazepine is a CYP3A4 inducer and can lower hydrocodone exposure, reducing analgesia or causing withdrawal in dependent patients. If the inducer is stopped, hydrocodone levels can rise and cause serious respiratory depression.
Что означает это взаимодействие простыми словами
Benzhydrocodone / acetaminophen and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Почему это происходит
CYP3A4 induction by oxcarbazepine increases hydrocodone clearance, and this reverses when the inducer is withdrawn.
Что делать
Monitor pain control and opioid withdrawal symptoms during coadministration. When oxcarbazepine is stopped or reduced, watch for sedation and respiratory depression and lower the opioid dose as needed.
О чём спросить фармацевта
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Другие взаимодействия Oxcarbazepine
- Cabotegravir + Oxcarbazepine Противопоказано
- Oxcarbazepine + Rilpivirine Противопоказано
- Artemether / lumefantrine + Oxcarbazepine Тяжёлое
- Atazanavir + Oxcarbazepine Тяжёлое
- Bictegravir + Oxcarbazepine Тяжёлое
- Bosutinib + Oxcarbazepine Тяжёлое
Частые вопросы
Can I take Benzhydrocodone / acetaminophen with Oxcarbazepine?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxcarbazepine is a CYP3A4 inducer and can lower hydrocodone exposure, reducing analgesia or causing withdrawal in dependent patients. If the inducer is stopped, hydrocodone levels can rise and cause serious respiratory depression.
How serious is the interaction between Benzhydrocodone / acetaminophen and Oxcarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and opioid withdrawal symptoms during coadministration. When oxcarbazepine is stopped or reduced, watch for sedation and respiratory depression and lower the opioid dose as needed.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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