Лекарственные взаимодействия
Bromocriptine + Phenylephrine
Тяжесть: Тяжёлое
Bromocriptine and Phenylephrine: major interaction.
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Кратко
Bromocriptine has been associated with hypertension and rarely arrhythmias, and combining it with a vasopressor such as phenylephrine may produce a greater rise in blood pressure. Severe hypertension, headache and cardiac events have been reported with ergot-type agents plus sympathomimetics.
Что означает это взаимодействие простыми словами
Bromocriptine and Phenylephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bromocriptine belongs to Central Nervous System; Phenylephrine belongs to Respiratory.
Почему это происходит
Additive vasoconstrictive and pressor effects through pharmacodynamic synergism.
Что делать
Avoid concomitant decongestant use with bromocriptine where possible and monitor blood pressure closely if phenylephrine is required. Stop therapy and seek care for severe headache or marked hypertension.
О чём спросить фармацевта
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Другие взаимодействия Phenylephrine
- Isocarboxazid + Phenylephrine Противопоказано
- Phenelzine + Phenylephrine Противопоказано
- Phenylephrine + Tranylcypromine Противопоказано
- Cocaine + Phenylephrine Тяжёлое
- Dihydroergotamine intranasal + Phenylephrine Тяжёлое
- Dihydroergotamine + Phenylephrine Тяжёлое
Другие взаимодействия Bromocriptine
- Amisulpride + Bromocriptine Тяжёлое
- Atazanavir + Bromocriptine Тяжёлое
- Bromocriptine + Cobicistat Тяжёлое
- Bromocriptine + Darunavir Тяжёлое
- Bromocriptine + Dihydroergotamine Тяжёлое
- Bromocriptine + Dihydroergotamine intranasal Тяжёлое
Частые вопросы
Can I take Bromocriptine with Phenylephrine?
MediHelp rates the interaction as major. Bromocriptine and Phenylephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bromocriptine has been associated with hypertension and rarely arrhythmias, and combining it with a vasopressor such as phenylephrine may produce a greater rise in blood pressure. Severe hypertension, headache and cardiac events have been reported with ergot-type agents plus sympathomimetics.
How serious is the interaction between Bromocriptine and Phenylephrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant decongestant use with bromocriptine where possible and monitor blood pressure closely if phenylephrine is required. Stop therapy and seek care for severe headache or marked hypertension.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Phenylephrine page.
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