Лекарственные взаимодействия
Buprenorphine long-acting + Phenelzine
Тяжесть: Противопоказано
Buprenorphine long-acting and Phenelzine: contraindicated interaction.
Последнее обновление
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Кратко
Combining an MAO inhibitor with buprenorphine may cause serotonin syndrome or opioid toxicity, including respiratory depression and coma. Long-acting injectable buprenorphine cannot be quickly withdrawn, which prolongs exposure if a reaction occurs. Labeling advises against use during or within 14 days of MAOI therapy.
Что означает это взаимодействие простыми словами
Buprenorphine long-acting and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Почему это происходит
Additive serotonergic effects and potentiation of opioid CNS and respiratory depression, possibly through altered opioid metabolism, in the setting of MAO inhibition.
Что делать
Do not start long-acting buprenorphine within 14 days of stopping phenelzine or while it is being taken. Choose a non-serotonergic alternative or allow an adequate washout.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Другие взаимодействия Phenelzine
- 5-HTP + Phenelzine Противопоказано
- Amitriptyline + Phenelzine Противопоказано
- Amoxapine + Phenelzine Противопоказано
- Atomoxetine + Phenelzine Противопоказано
- Benzphetamine + Phenelzine Противопоказано
- Brimonidine + Phenelzine Противопоказано
Частые вопросы
Can I take Buprenorphine long-acting with Phenelzine?
MediHelp rates the interaction as contraindicated. Buprenorphine long-acting and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an MAO inhibitor with buprenorphine may cause serotonin syndrome or opioid toxicity, including respiratory depression and coma. Long-acting injectable buprenorphine cannot be quickly withdrawn, which prolongs exposure if a reaction occurs. Labeling advises against use during or within 14 days of MAOI therapy.
How serious is the interaction between Buprenorphine long-acting and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not start long-acting buprenorphine within 14 days of stopping phenelzine or while it is being taken. Choose a non-serotonergic alternative or allow an adequate washout.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
Полные монографии, дозировки и проверка взаимодействий в приложении MediHelp
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