Лекарственные взаимодействия
Cholera vaccine + Rifaximin
Тяжесть: Тяжёлое
Cholera vaccine and Rifaximin: major interaction.
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Кратко
The oral live attenuated cholera vaccine needs viable bacteria to colonize and stimulate immunity. Antibiotics active against V. cholerae could lower the immune response. Rifaximin has activity against many enteric bacteria and acts locally in the gut, where the vaccine strain must establish.
Что означает это взаимодействие простыми словами
Cholera vaccine and Rifaximin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Почему это происходит
Luminal antibacterial activity in the gut can reduce viability and colonization of the live attenuated vaccine strain.
Что делать
Do not give the vaccine to patients who have recently had antibiotics; follow the labeled interval after the antibiotic course (14 days is stated in labeling). Delay the vaccine rather than the antibiotic when treatment is needed.
О чём спросить фармацевта
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Другие взаимодействия Rifaximin
- Microbiota + Rifaximin Тяжёлое
- Amiodarone + Rifaximin Умеренное
- Bcg intravesical live + Rifaximin Умеренное
- Cyclosporine + Rifaximin Умеренное
- Cyclosporin + Rifaximin Умеренное
- Dronedarone + Rifaximin Умеренное
Частые вопросы
Can I take Cholera vaccine with Rifaximin?
MediHelp rates the interaction as major. Cholera vaccine and Rifaximin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The oral live attenuated cholera vaccine needs viable bacteria to colonize and stimulate immunity. Antibiotics active against V. cholerae could lower the immune response. Rifaximin has activity against many enteric bacteria and acts locally in the gut, where the vaccine strain must establish.
How serious is the interaction between Cholera vaccine and Rifaximin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the vaccine to patients who have recently had antibiotics; follow the labeled interval after the antibiotic course (14 days is stated in labeling). Delay the vaccine rather than the antibiotic when treatment is needed.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Microbiota, Amiodarone, Bcg intravesical live. The full list is on the Rifaximin page.
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