Лекарственные взаимодействия
Ciprofloxacin + Glyburide
Тяжесть: Тяжёлое
Ciprofloxacin and Glyburide: major interaction.
Последнее обновление
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Кратко
Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients taking sulfonylureas. Severe hypoglycemia, including cases needing hospitalization, has been reported with ciprofloxacin and glyburide, and the risk is higher in older or renally impaired patients. Ciprofloxacin may also modestly raise glyburide exposure.
Что означает это взаимодействие простыми словами
Ciprofloxacin and Glyburide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ciprofloxacin belongs to Anti Bacterial; Glyburide belongs to Endocrine.
Почему это происходит
Fluoroquinolone effects on beta-cell insulin release add to sulfonylurea stimulation of insulin secretion, and ciprofloxacin may also reduce glyburide clearance.
Что делать
Monitor blood glucose frequently during and after the antibiotic course and teach the patient to recognize hypoglycemia. Reduce the glyburide dose if glucose falls, or choose a non-fluoroquinolone antibiotic.
О чём спросить фармацевта
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Другие взаимодействия Ciprofloxacin
- Agomelatine + Ciprofloxacin Противопоказано
- Ciprofloxacin + Fezolinetant Противопоказано
- Ciprofloxacin + Thioridazine Противопоказано
- Ciprofloxacin + Tizanidine Противопоказано
- Ciprofloxacin + Vandetanib Противопоказано
- Alosetron + Ciprofloxacin Тяжёлое
Другие взаимодействия Glyburide
- Bosentan + Glyburide Противопоказано
- Cholic acid + Glyburide Тяжёлое
- Clarithromycin + Glyburide Тяжёлое
- Fluconazole + Glyburide Тяжёлое
- Glyburide + Insulin degludec-liraglutide Тяжёлое
- Glyburide + Miconazole Тяжёлое
Частые вопросы
Can I take Ciprofloxacin with Glyburide?
MediHelp rates the interaction as major. Ciprofloxacin and Glyburide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients taking sulfonylureas. Severe hypoglycemia, including cases needing hospitalization, has been reported with ciprofloxacin and glyburide, and the risk is higher in older or renally impaired patients. Ciprofloxacin may also modestly raise glyburide exposure.
How serious is the interaction between Ciprofloxacin and Glyburide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during and after the antibiotic course and teach the patient to recognize hypoglycemia. Reduce the glyburide dose if glucose falls, or choose a non-fluoroquinolone antibiotic.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
Полные монографии, дозировки и проверка взаимодействий в приложении MediHelp
Откройте полный справочник, проверяйте взаимодействия нескольких препаратов и пользуйтесь инструментами дозирования в приложении MediHelp.
