Лекарственные взаимодействия
Dapagliflozin-metformin + Diatrizoate meglumine / diatrizoate
Тяжесть: Тяжёлое
Dapagliflozin-metformin and Diatrizoate meglumine / diatrizoate: major interaction.
Последнее обновление
Для специалистов здравоохранения — только для справки. Эта страница — краткая сводка, а не медицинская консультация и не замена официальной инструкции или клинического суждения. Всегда проверяйте перед назначением или отпуском.
Клиническое содержание этой страницы доступно только на английском языке.
Кратко
Intravascular iodinated contrast can cause acute kidney injury, and metformin accumulation in that setting raises the risk of lactic acidosis. This is rare but potentially serious, particularly in patients with impaired renal function.
Что означает это взаимодействие простыми словами
Dapagliflozin-metformin and Diatrizoate meglumine / diatrizoate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Почему это происходит
Contrast-induced decline in renal function reduces metformin elimination, leading to accumulation and lactic acidosis.
Что делать
Hold metformin at the time of or before the procedure in patients with eGFR below 30, in acute kidney injury, or with intra-arterial contrast. Re-check renal function about 48 hours afterward and restart metformin only if it is stable.
О чём спросить фармацевта
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Для подписчиков Pro+
Откройте страницу целиком
Создайте аккаунт и начните пробный период Pro+, чтобы открыть полные рекомендации по ведению для Dapagliflozin-metformin и Diatrizoate meglumine / diatrizoate, дополнительные примечания, подробности о доказательной базе и проверку взаимодействий для всего рецепта.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ бесплатно 14 дней на сайте. Карта не нужна.
Другие взаимодействия Dapagliflozin-metformin
Частые вопросы
Can I take Dapagliflozin-metformin with Diatrizoate meglumine / diatrizoate?
MediHelp rates the interaction as major. Dapagliflozin-metformin and Diatrizoate meglumine / diatrizoate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intravascular iodinated contrast can cause acute kidney injury, and metformin accumulation in that setting raises the risk of lactic acidosis. This is rare but potentially serious, particularly in patients with impaired renal function.
How serious is the interaction between Dapagliflozin-metformin and Diatrizoate meglumine / diatrizoate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin at the time of or before the procedure in patients with eGFR below 30, in acute kidney injury, or with intra-arterial contrast. Re-check renal function about 48 hours afterward and restart metformin only if it is stable.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Ethanol. The full list is on the Dapagliflozin-metformin page.
Полные монографии, дозировки и проверка взаимодействий в приложении MediHelp
Откройте полный справочник, проверяйте взаимодействия нескольких препаратов и пользуйтесь инструментами дозирования в приложении MediHelp.
