Лекарственные взаимодействия
Dinoprostone + Oxytocin
Тяжесть: Тяжёлое
Dinoprostone and Oxytocin: major interaction.
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Кратко
Dinoprostone and oxytocin both stimulate uterine contractions, and giving them close together can produce excessive uterine activity. This may lead to uterine tachysystole, fetal heart rate abnormalities, or uterine rupture, particularly in women with a previous uterine scar or high parity.
Что означает это взаимодействие простыми словами
Dinoprostone and Oxytocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dinoprostone belongs to Endocrine; Oxytocin belongs to Endocrine.
Почему это происходит
Additive pharmacodynamic uterotonic effects, with prostaglandin-induced sensitization of the myometrium to oxytocin.
Что делать
Allow an interval after removing dinoprostone (commonly at least 30 minutes for the vaginal insert, longer for gel per labeling) before starting oxytocin. Monitor uterine activity and fetal heart rate continuously.
О чём спросить фармацевта
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Другие взаимодействия Oxytocin
- Carboprost tromethamine + Oxytocin Тяжёлое
- Ephedrine + Oxytocin Тяжёлое
- Fexinidazole + Oxytocin Тяжёлое
- Givinostat + Oxytocin Тяжёлое
- Misoprostol + Oxytocin Тяжёлое
- Oxytocin + Phenylephrine Тяжёлое
Частые вопросы
Can I take Dinoprostone with Oxytocin?
MediHelp rates the interaction as major. Dinoprostone and Oxytocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dinoprostone and oxytocin both stimulate uterine contractions, and giving them close together can produce excessive uterine activity. This may lead to uterine tachysystole, fetal heart rate abnormalities, or uterine rupture, particularly in women with a previous uterine scar or high parity.
How serious is the interaction between Dinoprostone and Oxytocin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Allow an interval after removing dinoprostone (commonly at least 30 minutes for the vaginal insert, longer for gel per labeling) before starting oxytocin. Monitor uterine activity and fetal heart rate continuously.
What other medicines interact with Oxytocin?
MediHelp also lists interactions of Oxytocin with, for example, Carboprost tromethamine, Ephedrine, Fexinidazole. The full list is on the Oxytocin page.
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