Лекарственные взаимодействия
Fludrocortisone + Influenza virus vaccine quadrivalent intranasal
Тяжесть: Тяжёлое
Fludrocortisone and Influenza virus vaccine quadrivalent intranasal: major interaction.
Последнее обновление
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Кратко
The intranasal influenza vaccine is live attenuated. Corticosteroid-induced immunosuppression could allow vaccine virus replication and may also reduce the immune response. The risk is greater with higher or prolonged steroid exposure than with replacement-dose fludrocortisone.
Что означает это взаимодействие простыми словами
Fludrocortisone and Influenza virus vaccine quadrivalent intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Почему это происходит
Corticosteroid immunosuppression reduces control of live attenuated virus and blunts vaccine immunogenicity.
Что делать
Use an inactivated influenza vaccine instead in patients on systemic corticosteroids. Give the live intranasal vaccine only after specialist review and when steroid exposure is non-immunosuppressive.
О чём спросить фармацевта
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Другие взаимодействия Fludrocortisone
- Fludrocortisone + Mifepristone Противопоказано
- Aldesleukin + Fludrocortisone Тяжёлое
- Amphotericin b + Fludrocortisone Тяжёлое
- Bcg vaccine live + Fludrocortisone Тяжёлое
- Fludrocortisone + Measles mumps and rubella vaccine live Тяжёлое
- Fludrocortisone + Measles mumps rubella and varicella vaccine live Тяжёлое
Частые вопросы
Can I take Fludrocortisone with Influenza virus vaccine quadrivalent intranasal?
MediHelp rates the interaction as major. Fludrocortisone and Influenza virus vaccine quadrivalent intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The intranasal influenza vaccine is live attenuated. Corticosteroid-induced immunosuppression could allow vaccine virus replication and may also reduce the immune response. The risk is greater with higher or prolonged steroid exposure than with replacement-dose fludrocortisone.
How serious is the interaction between Fludrocortisone and Influenza virus vaccine quadrivalent intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an inactivated influenza vaccine instead in patients on systemic corticosteroids. Give the live intranasal vaccine only after specialist review and when steroid exposure is non-immunosuppressive.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
Полные монографии, дозировки и проверка взаимодействий в приложении MediHelp
Откройте полный справочник, проверяйте взаимодействия нескольких препаратов и пользуйтесь инструментами дозирования в приложении MediHelp.
