Лекарственные взаимодействия
Magnesium citrate + Sodium polystyrene sulfonate
Тяжесть: Умеренное
Magnesium citrate and Sodium polystyrene sulfonate: moderate interaction.
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Кратко
Sodium polystyrene sulfonate binds cations in the gut including magnesium, and can cause hypomagnesemia. Magnesium-containing laxatives may also bind to the resin and, with non-absorbable cation exchangers, have been associated with metabolic alkalosis because the resin's buffering of bicarbonate is reduced.
Что означает это взаимодействие простыми словами
Magnesium citrate and Sodium polystyrene sulfonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium citrate belongs to Gastrointestinal Tract; Sodium polystyrene sulfonate belongs to Miscellaneous.
Почему это происходит
Cation exchange resin binds magnesium in the gut, and binding of magnesium reduces neutralization of bicarbonate, which can lead to systemic alkalosis.
Что делать
Avoid giving magnesium-containing laxatives or antacids with the resin, and separate other oral drugs by at least 3 hours. Monitor serum electrolytes and acid-base status during therapy.
О чём спросить фармацевта
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Другие взаимодействия Magnesium citrate
- Ciprofloxacin + Magnesium citrate Тяжёлое
- Baloxavir marboxil + Magnesium citrate Умеренное
- Bictegravir + Magnesium citrate Умеренное
- Cabotegravir + Magnesium citrate Умеренное
- Cholecalciferol + Magnesium citrate Умеренное
- Deferiprone + Magnesium citrate Умеренное
Другие взаимодействия Sodium polystyrene sulfonate
- Meloxicam + Sodium polystyrene sulfonate Тяжёлое
- Sodium polystyrene sulfonate + Sorbitol Тяжёлое
- Calcium carbonate + Sodium polystyrene sulfonate Умеренное
- Deflazacort + Sodium polystyrene sulfonate Умеренное
- Levothyroxine + Sodium polystyrene sulfonate Умеренное
- Lithium + Sodium polystyrene sulfonate Умеренное
Частые вопросы
Can I take Magnesium citrate with Sodium polystyrene sulfonate?
MediHelp rates the interaction as moderate. Magnesium citrate and Sodium polystyrene sulfonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium polystyrene sulfonate binds cations in the gut including magnesium, and can cause hypomagnesemia. Magnesium-containing laxatives may also bind to the resin and, with non-absorbable cation exchangers, have been associated with metabolic alkalosis because the resin's buffering of bicarbonate is reduced.
How serious is the interaction between Magnesium citrate and Sodium polystyrene sulfonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving magnesium-containing laxatives or antacids with the resin, and separate other oral drugs by at least 3 hours. Monitor serum electrolytes and acid-base status during therapy.
What other medicines interact with Magnesium citrate?
MediHelp also lists interactions of Magnesium citrate with, for example, Ciprofloxacin, Baloxavir marboxil, Bictegravir. The full list is on the Magnesium citrate page.
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