Лекарственные взаимодействия
Measles mumps and rubella vaccine live + Melphalan
Тяжесть: Противопоказано
Measles mumps and rubella vaccine live and Melphalan: contraindicated interaction.
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Кратко
MMR vaccine contains live attenuated viruses, which can replicate without control in a patient immunosuppressed by melphalan. This can lead to disseminated vaccine-virus disease, and the vaccine response is also reduced.
Что означает это взаимодействие простыми словами
Measles mumps and rubella vaccine live and Melphalan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Почему это происходит
Chemotherapy-induced immunosuppression allows unchecked replication of live attenuated virus and impairs the vaccine response.
Что делать
Avoid live vaccines during melphalan therapy and for at least 3 months after it ends, subject to immune recovery. Give live vaccines at least 4 weeks before starting chemotherapy when possible.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Другие взаимодействия Melphalan
- Adenovirus types 4 and 7 live + Melphalan Противопоказано
- Bcg vaccine live + Melphalan Противопоказано
- Influenza virus vaccine quadrivalent intranasal + Melphalan Противопоказано
- Measles mumps and rubella vaccine + Melphalan Противопоказано
- Measles mumps rubella and varicella vaccine live + Melphalan Противопоказано
- Measles vaccine + Melphalan Противопоказано
Частые вопросы
Can I take Measles mumps and rubella vaccine live with Melphalan?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine live and Melphalan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MMR vaccine contains live attenuated viruses, which can replicate without control in a patient immunosuppressed by melphalan. This can lead to disseminated vaccine-virus disease, and the vaccine response is also reduced.
How serious is the interaction between Measles mumps and rubella vaccine live and Melphalan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during melphalan therapy and for at least 3 months after it ends, subject to immune recovery. Give live vaccines at least 4 weeks before starting chemotherapy when possible.
What other medicines interact with Melphalan?
MediHelp also lists interactions of Melphalan with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Melphalan page.
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