Лекарственные взаимодействия
Methyldopa + Tranylcypromine
Тяжесть: Противопоказано
Methyldopa and Tranylcypromine: contraindicated interaction.
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Кратко
MAO inhibitors are listed as contraindicated with methyldopa in labeling because of the risk of hypertensive reactions and excitation, and tranylcypromine may also oppose the hypotensive effect. Methyldopa is metabolised to catecholamine-like compounds that can be potentiated when MAO is inhibited.
Что означает это взаимодействие простыми словами
Methyldopa and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Methyldopa belongs to Cardiovascular; Tranylcypromine belongs to Central Nervous System.
Почему это происходит
MAO inhibition prevents breakdown of methyldopa-derived catecholamine metabolites, causing excess adrenergic stimulation.
Что делать
Do not combine. Allow an adequate washout, about 14 days after stopping the MAOI, before starting methyldopa, and choose another antihypertensive.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Другие взаимодействия Methyldopa
- Iobenguane i + Methyldopa Тяжёлое
- Lofexidine + Methyldopa Тяжёлое
- Methyldopa + Pexidartinib Тяжёлое
- Methyldopa + Pretomanid Тяжёлое
- Methyldopa + Thioridazine Тяжёлое
- Adrenaline-articaine + Methyldopa Умеренное
Другие взаимодействия Tranylcypromine
- 5-HTP + Tranylcypromine Противопоказано
- Amitriptyline + Tranylcypromine Противопоказано
- Amoxapine + Tranylcypromine Противопоказано
- Atomoxetine + Tranylcypromine Противопоказано
- Benzphetamine + Tranylcypromine Противопоказано
- Brimonidine + Tranylcypromine Противопоказано
Частые вопросы
Can I take Methyldopa with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Methyldopa and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAO inhibitors are listed as contraindicated with methyldopa in labeling because of the risk of hypertensive reactions and excitation, and tranylcypromine may also oppose the hypotensive effect. Methyldopa is metabolised to catecholamine-like compounds that can be potentiated when MAO is inhibited.
How serious is the interaction between Methyldopa and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Allow an adequate washout, about 14 days after stopping the MAOI, before starting methyldopa, and choose another antihypertensive.
What other medicines interact with Methyldopa?
MediHelp also lists interactions of Methyldopa with, for example, Iobenguane i, Lofexidine, Pexidartinib. The full list is on the Methyldopa page.
Полные монографии, дозировки и проверка взаимодействий в приложении MediHelp
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