ادویات کا حوالہ
Nelarabine
Nelarabine is a medicine in the class oncology. It is used for acute lymphocytic leukemia.
- دوا کا طبقہ: Oncology
- استعمال: acute lymphocytic leukemia
آخری تازہ کاری ماخذ: US FDA label
صرف صحت کے پیشہ ور افراد کے لیے — محض حوالے کے طور پر۔ یہ صفحہ مختصر خلاصہ ہے، طبی مشورہ نہیں، اور سرکاری لیبل یا طبی فیصلے کا متبادل نہیں۔ تجویز یا فراہمی سے پہلے ہمیشہ تصدیق کریں۔
اس صفحے کا طبی مواد صرف انگریزی میں دستیاب ہے۔
اہم نکات
- دوا کا طبقہ
- Oncology
- ATC کوڈ
- L01BB07
- عام شکلیں
- انجکشن
- عام طاقتیں
- 5 mg/ml
- معلوم تعاملات
- 9 (شدید: 4 · معتدل: 4 · معمولی: 1)
- تجارتی نام
- 2
- ممالک اور مارکیٹیں
- 2
یہ کس لیے استعمال ہوتی ہے
یہ کیسے کام کرتی ہے
Nelarabine is a prodrug of ara-G, a nucleoside metabolic inhibitor. It is demethylated by ADA to ara-G and converted to the active triphosphate ara-GTP, which is incorporated into DNA, inhibiting DNA synthesis and causing cell death.
بالغوں کی عام خوراک (لیبل کا خلاصہ)
Relapsed or refractory T-ALL/T-LBL: 1,500 mg/m2 by intravenous infusion over 2 hours on Days 1, 3, and 5, repeated every 21 days; administer undiluted
حمل اور دودھ پلانا
- حمل
- Unsafe Can cause fetal harm: it was teratogenic in rabbits at doses below the human dose; human data are too limited. Check pregnancy status before starting; women should use effective contraception during treatment and men should use condoms during and for 3 months after.
- دودھ پلانا
- Unsafe No data on milk levels. e-lactancia: incompatible; a small, poorly protein-bound molecule likely to pass into milk. US label: do not breastfeed during treatment because of possible serious infant reactions, such as severe nerve toxicity.
رپورٹ شدہ ضمنی اثرات
- Anemia
- Thrombocytopenia
- Neutropenia
- Fatigue
- Nausea
- Cough
نمایاں انتباہات
- Severe neurologic adverse reactions have occurred, including altered mental states with severe somnolence, convulsions, peripheral neuropathy from numbness and paresthesias to weakness and paralysis, demyelination, and ascending neuropathy similar to Guillain-Barré syndrome. Full recovery has not always occurred after stopping therapy. Monitor frequently for neurologic toxicity and discontinue for CTCAE Grade 2 or greater neurologic reactions.
کسے احتیاط کرنی چاہیے
- Neurologic toxicity: monitor during and for at least 24 hours after treatment. Prior or concurrent intrathecal chemotherapy or prior craniospinal irradiation may increase risk.
- Hematologic toxicity: leukopenia, thrombocytopenia, anemia and neutropenia; monitor complete blood counts including platelets regularly.
- Embryo-fetal toxicity: can cause fetal harm; verify pregnancy status, use effective contraception, and males should use condoms during treatment and for 3 months after the last dose.
اپنے فارماسسٹ یا ڈاکٹر کو حمل یا دودھ پلانے، گردے یا جگر کے مرض، الرجی اور اپنی استعمال کی ہوئی ہر دوسری دوا یا سپلیمنٹ کے بارے میں بتائیں۔
اہم تعاملات (9)
- Deferiprone + Nelarabine Major
- Nelarabine + Pentostatin Major
- Nelarabine + Siponimod Major
- Nelarabine + Tofacitinib Major
- Denosumab + Nelarabine Moderate
- Fingolimod + Nelarabine Moderate
- Hydroxyurea + Nelarabine Moderate
- Nelarabine + Trastuzumab Moderate
- Nelarabine + Vitamin e Minor
Pro+ اراکین کے لیے
پورا صفحہ کھولیں
Nelarabine کا مکمل مونوگراف کھولنے کے لیے اکاؤنٹ بنائیں اور Pro+ ٹرائل شروع کریں: خوراک، حمل اور دودھ پلانا، ضمنی اثرات، انتباہات اور تمام تعاملات۔
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
ویب پر 14 دن تک Pro+ مفت آزمائیں۔ کارڈ کی ضرورت نہیں۔
اسی طبقے کی دیگر دوائیں
اکثر پوچھے جانے والے سوالات
What is Nelarabine used for?
Nelarabine is a medicine in the class oncology. It is used for Acute lymphocytic leukemia, Lymphoma.
What side effects have been reported with Nelarabine?
Anemia, Thrombocytopenia, Neutropenia, Fatigue, Nausea, Cough. Serious warning: Severe neurologic adverse reactions have occurred, including altered mental states with severe somnolence, convulsions, peripheral neuropathy from numbness and paresthesias to weakness and paralysis, demyelination, and ascending neuropathy similar to Guillain-Barré syndrome.
Can Nelarabine be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: it was teratogenic in rabbits at doses below the human dose; human data are too limited. Check pregnancy status before starting; women should use effective contraception during treatment and men should use condoms during and for 3 months after. Breastfeeding: Unsafe. No data on milk levels. e-lactancia: incompatible; a small, poorly protein-bound molecule likely to pass into milk. US label: do not breastfeed during treatment because of possible serious infant reactions, such as severe nerve toxicity.
What does Nelarabine interact with?
MediHelp lists 9 known interactions for Nelarabine. Major: 4 · Moderate: 4 · Minor: 1. The most serious include Deferiprone, Pentostatin, Siponimod.
MediHelp ایپ میں مکمل مونوگراف، خوراک اور تعامل چیکر
MediHelp ایپ میں مکمل حوالہ کھولیں، متعدد ادویات کے تعاملات جانچیں اور خوراک کے ٹولز استعمال کریں۔
