دوا کے تعاملات
Dihydroergotamine + Miconazole
شدت: شدید
Dihydroergotamine and Miconazole: major interaction.
آخری تازہ کاری
صرف صحت کے پیشہ ور افراد کے لیے — محض حوالے کے طور پر۔ یہ صفحہ مختصر خلاصہ ہے، طبی مشورہ نہیں، اور سرکاری لیبل یا طبی فیصلے کا متبادل نہیں۔ تجویز یا فراہمی سے پہلے ہمیشہ تصدیق کریں۔
اس صفحے کا طبی مواد صرف انگریزی میں دستیاب ہے۔
خلاصہ
Dihydroergotamine is cleared mainly by CYP3A4, and strong inhibition of this enzyme can raise ergot levels sharply, causing ergotism with severe peripheral and cerebral vasospasm and ischemia. Miconazole is a CYP3A4 inhibitor and, although vaginal absorption is low, systemic exposure can occur and ergot toxicity is potentially catastrophic.
اس تعامل کا آسان لفظوں میں مطلب
Dihydroergotamine and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dihydroergotamine belongs to Central Nervous System; Miconazole belongs to Anti Fungals.
ایسا کیوں ہوتا ہے
Miconazole inhibits CYP3A4-mediated metabolism of dihydroergotamine, increasing its systemic concentrations.
کیا کرنا ہے
Avoid the combination where possible, and prefer a topical antifungal with minimal absorption or an alternative to the ergot. If used together, counsel the patient to report numbness, cold or painful extremities, or chest pain immediately.
فارماسسٹ سے کیا پوچھیں
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ اراکین کے لیے
پورا صفحہ کھولیں
Dihydroergotamine اور Miconazole کے لیے مکمل طبی انتظام کی رہنمائی، اضافی نوٹس، شواہد کی تفصیل اور پورے نسخے کا تعامل چیکر کھولنے کے لیے اکاؤنٹ بنائیں اور Pro+ ٹرائل شروع کریں۔
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
ویب پر 7 دن تک Pro+ مفت آزمائیں۔ کارڈ کی ضرورت نہیں۔
Miconazole کے دیگر تعاملات
Dihydroergotamine کے دیگر تعاملات
- Almotriptan + Dihydroergotamine مانع استعمال
- Clarithromycin + Dihydroergotamine مانع استعمال
- Dihydroergotamine + Dopamine مانع استعمال
- Dihydroergotamine + Dronedarone مانع استعمال
- Dihydroergotamine + Efavirenz مانع استعمال
- Dihydroergotamine + Eletriptan مانع استعمال
اکثر پوچھے جانے والے سوالات
Can I take Dihydroergotamine with Miconazole?
MediHelp rates the interaction as major. Dihydroergotamine and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dihydroergotamine is cleared mainly by CYP3A4, and strong inhibition of this enzyme can raise ergot levels sharply, causing ergotism with severe peripheral and cerebral vasospasm and ischemia. Miconazole is a CYP3A4 inhibitor and, although vaginal absorption is low, systemic exposure can occur and ergot toxicity is potentially catastrophic.
How serious is the interaction between Dihydroergotamine and Miconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, and prefer a topical antifungal with minimal absorption or an alternative to the ergot. If used together, counsel the patient to report numbness, cold or painful extremities, or chest pain immediately.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Ergotamine. The full list is on the Miconazole page.
MediHelp ایپ میں مکمل مونوگراف، خوراک اور تعامل چیکر
MediHelp ایپ میں مکمل حوالہ کھولیں، متعدد ادویات کے تعاملات جانچیں اور خوراک کے ٹولز استعمال کریں۔
