دوا کے تعاملات
Folic Acid + Methotrexate
شدت: معتدل
Folic Acid and Methotrexate: moderate interaction.
آخری تازہ کاری ماخذ: US FDA label
صرف صحت کے پیشہ ور افراد کے لیے — محض حوالے کے طور پر۔ یہ صفحہ مختصر خلاصہ ہے، طبی مشورہ نہیں، اور سرکاری لیبل یا طبی فیصلے کا متبادل نہیں۔ تجویز یا فراہمی سے پہلے ہمیشہ تصدیق کریں۔
اس صفحے کا طبی مواد صرف انگریزی میں دستیاب ہے۔
خلاصہ
Folic acid is routinely co-prescribed with low-dose weekly methotrexate to reduce nausea, mouth ulcers, and liver enzyme elevations without meaningfully reducing efficacy in rheumatoid arthritis or psoriasis. In oncology, folate supplementation could theoretically reduce the antineoplastic effect of methotrexate, particularly at high doses, so it is not given outside protocols.
اس تعامل کا آسان لفظوں میں مطلب
Folic Acid and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Folic Acid belongs to Miscellaneous; Methotrexate belongs to Oncology.
ایسا کیوں ہوتا ہے
Pharmacodynamic antagonism: methotrexate inhibits dihydrofolate reductase, and folate repletion restores folate-dependent pathways in normal cells, reducing toxicity.
کیا کرنا ہے
For low-dose weekly methotrexate in rheumatologic or dermatologic disease, give folic acid at a typical dose of 5 mg weekly or 1 mg daily, commonly on a day other than the methotrexate dose. Monitor blood counts, liver enzymes, and renal function regularly, and assess disease control.
فارماسسٹ سے کیا پوچھیں
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ اراکین کے لیے
پورا صفحہ کھولیں
Folic Acid اور Methotrexate کے لیے مکمل طبی انتظام کی رہنمائی، اضافی نوٹس، شواہد کی تفصیل اور پورے نسخے کا تعامل چیکر کھولنے کے لیے اکاؤنٹ بنائیں اور Pro+ ٹرائل شروع کریں۔
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
ویب پر 7 دن تک Pro+ مفت آزمائیں۔ کارڈ کی ضرورت نہیں۔
حوالہ جات
- Methotrexate Injection/Tablets Prescribing Information - Drug Interactions — FDA Label
- 2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis — ACR Guideline
Methotrexate کے دیگر تعاملات
- Acitretin + Methotrexate مانع استعمال
- Adenovirus types 4 and 7 live + Methotrexate مانع استعمال
- Influenza virus vaccine quadrivalent intranasal + Methotrexate مانع استعمال
- Ketorolac + Methotrexate مانع استعمال
- Measles mumps and rubella vaccine live + Methotrexate مانع استعمال
- Measles mumps and rubella vaccine + Methotrexate مانع استعمال
Folic Acid کے دیگر تعاملات
اکثر پوچھے جانے والے سوالات
Can I take Folic Acid with Methotrexate?
MediHelp rates the interaction as moderate. Folic Acid and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Folic acid is routinely co-prescribed with low-dose weekly methotrexate to reduce nausea, mouth ulcers, and liver enzyme elevations without meaningfully reducing efficacy in rheumatoid arthritis or psoriasis. In oncology, folate supplementation could theoretically reduce the antineoplastic effect of methotrexate, particularly at high doses, so it is not given outside protocols.
How serious is the interaction between Folic Acid and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For low-dose weekly methotrexate in rheumatologic or dermatologic disease, give folic acid at a typical dose of 5 mg weekly or 1 mg daily, commonly on a day other than the methotrexate dose. Monitor blood counts, liver enzymes, and renal function regularly, and assess disease control.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
MediHelp ایپ میں مکمل مونوگراف، خوراک اور تعامل چیکر
MediHelp ایپ میں مکمل حوالہ کھولیں، متعدد ادویات کے تعاملات جانچیں اور خوراک کے ٹولز استعمال کریں۔
