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NAPLEX Pharmacotherapy Foundations

Top 200 drugs and key interactions. Original NAPLEX-style single-best-answer questions on the most commonly dispensed drugs: mechanism, indications, adverse effects, interactions, dosing, counselling, special populations and pharmacy calculations. Every question has a concise explanation and public references (FDA labels via DailyMed, NCBI Bookshelf, FDA). Aligned to the NABP NAPLEX Content Outline domains (Foundational Knowledge, Medication Use Process, Person-Centered Assessment and Treatment Planning). Educational use only; not an official NABP product.

App Store Google Play 試做 5 題免費試題

涵蓋範圍

  • 藥物交互作用 (27)
  • 不良反應 (24)
  • 作用機轉 (22)
  • 適應症 (20)
  • 藥學計算 (15)
  • 用藥指導 (15)
  • 劑量 (14)
  • 特殊族群 (13)

150 題

難度分布

  • 簡單48 (32%)
  • 中等76 (51%)
  • 困難26 (17%)

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試做 5 題免費試題

1 / 5 · 作用機轉

Apixaban prevents stroke in non-valvular atrial fibrillation by which mechanism?

  1. Inhibition of vitamin K epoxide reductase
  2. Inhibition of glycoprotein IIb/IIIa
  3. Direct inhibition of thrombin (factor IIa)
  4. Direct, selective inhibition of free and clot-bound factor Xa
  5. Binding antithrombin to accelerate factor Xa inactivation
顯示答案與解析

正確答案: D. Direct, selective inhibition of free and clot-bound factor Xa

Apixaban, rivaroxaban and edoxaban are direct factor Xa inhibitors that do not require antithrombin. Dabigatran is the oral direct thrombin inhibitor, and heparins act through antithrombin.

2 / 5 · 藥物交互作用

A patient who takes atorvastatin drinks large amounts of grapefruit juice. What is the pharmacist's best advice?

  1. Limit grapefruit juice because intestinal CYP3A4 inhibition can raise atorvastatin levels
  2. Grapefruit juice lowers atorvastatin efficacy, so take double the dose
  3. Grapefruit juice only matters with penicillins
  4. Grapefruit has no interactions with any drug
  5. Take the statin only in the morning to avoid the effect
顯示答案與解析

正確答案: A. Limit grapefruit juice because intestinal CYP3A4 inhibition can raise atorvastatin levels

Grapefruit juice irreversibly inhibits intestinal CYP3A4; the effect is greater for simvastatin and lovastatin than atorvastatin, but large quantities (over 1.2 L per day) may raise exposure. Pravastatin and rosuvastatin are unaffected.

3 / 5 · 藥學計算

You need 50 mL of a 2% solution and have a 10% stock solution. How many mL of stock are required?

  1. 10 mL
  2. 25 mL
  3. 5 mL
  4. 20 mL
  5. 2 mL
顯示答案與解析

正確答案: A. 10 mL

C1V1 = C2V2: 10% x V1 = 2% x 50 mL, so V1 = 100 / 10 = 10 mL; add 40 mL of diluent.

4 / 5 · 不良反應

A patient on simvastatin reports new diffuse muscle pain and dark urine. What is the most appropriate action?

  1. Add ezetimibe and continue
  2. Stop the statin and obtain creatine kinase and renal function urgently
  3. Take the statin at night only
  4. Continue and recheck in 6 months
  5. Double the dose
顯示答案與解析

正確答案: B. Stop the statin and obtain creatine kinase and renal function urgently

Statin-associated rhabdomyolysis presents with myalgia, weakness and myoglobinuria and can cause acute kidney injury. Risk factors include high dose, interacting drugs, hypothyroidism, renal disease and older age.

5 / 5 · 劑量

What INR range is typical for a patient on warfarin for non-valvular AF or VTE?

  1. 1.0 to 1.5
  2. 4.0 to 5.0
  3. 2.0 to 3.0
  4. 3.5 to 4.5
  5. 0.8 to 1.2
顯示答案與解析

正確答案: C. 2.0 to 3.0

A target INR of 2.5 (range 2-3) applies to most indications; mechanical mitral valves generally target 3 (2.5-3.5). Time in therapeutic range correlates with outcomes.

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