Diseases
hypoprothrombinemia
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
hypoprothrombinemia, disease characterized by a deficiency of the blood-clotting substance prothrombin, resulting in a tendency to prolonged bleeding. Hypoprothrombinemia is usually associated with a lack of vitamin K, which is necessary for the synthesis of prothrombin in the liver cells.
Symptoms
- easy bruising.
- epistaxis.
- prolonged bleeding with injury, tooth extraction, or surgery.
- oral mucosal bleeding.
- melena
Causes
- vitamin k deficiency
- severe liver disease
- disseminated intravascular coagulation (dic)
Risk factors
- warfarin overdose
- lack of vitamin k
Diagnosis
- prothrombin time (pt) test
- activated partial thromboplastin time (aptt) test
Medicines used
Frequently asked questions
What is hypoprothrombinemia?
hypoprothrombinemia, disease characterized by a deficiency of the blood-clotting substance prothrombin, resulting in a tendency to prolonged bleeding. Hypoprothrombinemia is usually associated with a lack of vitamin K, which is necessary for the synthesis of prothrombin in the liver cells.
What are the symptoms of hypoprothrombinemia?
easy bruising., epistaxis., prolonged bleeding with injury, tooth extraction, or surgery., oral mucosal bleeding., melena
What causes hypoprothrombinemia?
vitamin k deficiency; severe liver disease; disseminated intravascular coagulation (dic)
Which medicines are used for hypoprothrombinemia?
vitamin k, vitamin k1
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