Diseases
myelofibrosis
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Myelofibrosis is an uncommon type of bone marrow cancer that disrupts your body's normal production of blood cells. Myelofibrosis causes extensive scarring in your bone marrow, leading to severe anemia that can cause weakness and fatigue.
Symptoms
- feeling tired, weak or short of breath, usually because of anemia
- pain or fullness below your ribs on the left side, due to an enlarged spleen
- easy bruising
- easy bleeding
- excessive sweating during sleep (night sweats)
Causes
- myelofibrosis occurs when bone marrow stem cells develop changes (mutations) in their dna.
Risk factors
- age: most often diagnosed in people older than 50.
- another blood cell disorder.
- exposure to certain chemicals.
Diagnosis
- blood test.
- physical exam.
- imaging tests
- bone marrow examination.
Medicines used
Frequently asked questions
What is myelofibrosis?
Myelofibrosis is an uncommon type of bone marrow cancer that disrupts your body's normal production of blood cells. Myelofibrosis causes extensive scarring in your bone marrow, leading to severe anemia that can cause weakness and fatigue.
What are the symptoms of myelofibrosis?
feeling tired, weak or short of breath, usually because of anemia, pain or fullness below your ribs on the left side, due to an enlarged spleen, easy bruising, easy bleeding, excessive sweating during sleep (night sweats)
What causes myelofibrosis?
myelofibrosis occurs when bone marrow stem cells develop changes (mutations) in their dna.
Which medicines are used for myelofibrosis?
ruxolitinib
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