Diseases
valproic acid overdose
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Manifestations of acute valproic acid toxicity are myriad, and reflect both exaggerated therapeutic effect and impaired intermediary metabolism. Central nervous system depression is the most common finding noted in overdose, and may progress to coma and respiratory depression. Cerebral edema has also been observed.
Symptoms
- coma
- confusion
- dizziness
- somnolence
- worsened seizure control.
Causes
- toxicity can occur with dose adjustments to reach the therapeutic level, in patients with metabolic derangements, with drug-drug interactions, or in attempts to cause self-harm.
Risk factors
- being on valproic acid
- drug interacting with the metabolism or pharmacokinetics of valproic acid
Diagnosis
- blood test.
- physical exam.
Medicines used
Frequently asked questions
What is valproic acid overdose?
Manifestations of acute valproic acid toxicity are myriad, and reflect both exaggerated therapeutic effect and impaired intermediary metabolism. Central nervous system depression is the most common finding noted in overdose, and may progress to coma and respiratory depression. Cerebral edema has also been observed.
What are the symptoms of valproic acid overdose?
coma, confusion, dizziness, somnolence, worsened seizure control.
What causes valproic acid overdose?
toxicity can occur with dose adjustments to reach the therapeutic level, in patients with metabolic derangements, with drug-drug interactions, or in attempts to cause self-harm.
Which medicines are used for valproic acid overdose?
l-carnitine
Full monographs, dosing and an interaction checker in the MediHelp app
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