Diseases
vipoma
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
A vipoma is a non-beta pancreatic islet cell tumor secreting vasoactive intestinal peptide (VIP), resulting in a syndrome of watery diarrhea, hypokalemia, and achlorhydria (WDHA syndrome). Diagnosis is by serum VIP levels. Tumor is localized with CT and endoscopic ultrasound. Treatment is surgical resection.
Symptoms
- nausea
- lethargy
- vomiting
- muscular weakness
- crampy abdominal pain occur frequently.
Causes
- multiple endocrine neoplasia, type 1 (men 1) syndrome
- von hippel-lindau disease
Risk factors
- being male. men are much more likely than women to develop these tumors.
- a family history of pancreatic neuroendocrine tumors.
Diagnosis
- blood tests
- serum vasoactive intestinal peptide (vip) levels
- endoscopic ultrasonography, positron emission tomography (pet), or scintigraphy
- confirmation of secretory diarrhea
Medicines used
Frequently asked questions
What is vipoma?
A vipoma is a non-beta pancreatic islet cell tumor secreting vasoactive intestinal peptide (VIP), resulting in a syndrome of watery diarrhea, hypokalemia, and achlorhydria (WDHA syndrome). Diagnosis is by serum VIP levels. Tumor is localized with CT and endoscopic ultrasound. Treatment is surgical resection.
What are the symptoms of vipoma?
nausea, lethargy, vomiting, muscular weakness, crampy abdominal pain occur frequently.
What causes vipoma?
multiple endocrine neoplasia, type 1 (men 1) syndrome; von hippel-lindau disease
Which medicines are used for vipoma?
octreotide
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