Diseases
vitamin d-resistant rickets
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Hypophosphatemic rickets is a disorder characterized by hypophosphatemia, defective intestinal absorption of calcium, and rickets or osteomalacia unresponsive to vitamin D. It is usually hereditary. Symptoms are bone pain, fractures, and growth abnormalities.
Symptoms
- hypophosphatemia
- growth retardation
- short stature to severe rickets or osteomalacia.
Causes
- the cause of vitamin d resistant rickets is thought to be a defect of renal tubular mechanisms.
Risk factors
- dark skin has more of the pigment melanin.
- medications
- mother's vitamin d deficiency during pregnancy
Diagnosis
- serum levels of calcium, phosphate, alkaline phosphatase
- bone x-rays
- urinary phosphate and creatinine levels
Medicines used
Frequently asked questions
What is vitamin d-resistant rickets?
Hypophosphatemic rickets is a disorder characterized by hypophosphatemia, defective intestinal absorption of calcium, and rickets or osteomalacia unresponsive to vitamin D. It is usually hereditary. Symptoms are bone pain, fractures, and growth abnormalities.
What are the symptoms of vitamin d-resistant rickets?
hypophosphatemia, growth retardation, short stature to severe rickets or osteomalacia.
What causes vitamin d-resistant rickets?
the cause of vitamin d resistant rickets is thought to be a defect of renal tubular mechanisms.
Which medicines are used for vitamin d-resistant rickets?
alfacalcidol, cholecalciferol, ergocalciferol, vitamin d
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