Drug reference
fosinopril
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (ACE Inhibitors)
Mechanism of action
Angiotensin converting enzyme (ACE) inhibitors dilate arteries and veins by competively inhibiting the conversion of angiotensin I to angiotensin II (a potent endogenous vasoconstrictor) and by inhibiting bradykinin metabolism; these actions result in preload and afterload reductions on the heart
ACE inhibitors also promote sodium and water excretion by inhibiting angiotensin-II induced aldosterone secretion; elevation in potassium may also be observed
Common side effects
- Dizziness
- Headache
- Fatigue
- Hyperkalemia
- Cough
- Orthostatic hypotension
- Diarrhea
Boxed warnings
- Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system causing oligohydramnios, which may result in fetal injury and/or death
Contraindications
- Hypersensitivity to this product or any other ACE inhibitor Angioedema associated with prior ACE inhibitor treatment Coadministration with aliskiren in patients with diabetes mellitus
Known interactions (1)
- fosinopril + sacubitril-valsartan Contraindicated
Related conditions
Frequently asked questions
What drug class is fosinopril?
fosinopril belongs to: Cardiovascular.
How does fosinopril work?
Angiotensin converting enzyme (ACE) inhibitors dilate arteries and veins by competively inhibiting the conversion of angiotensin I to angiotensin II (a potent endogenous vasoconstrictor) and by inhibiting bradykinin metabolism; these actions result in preload and afterload reductions on the heart ACE inhibitors also promote sodium and water excretion by inhibiting angiotensin-II induced aldosterone secretion; elevation in potassium may also be observed
What are the common side effects of fosinopril?
Dizziness, Headache, Fatigue, Hyperkalemia, Cough, Orthostatic hypotension, Diarrhea
Which drugs interact with fosinopril?
sacubitril-valsartan
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.