Drug reference
irinotecan
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Oncology (Topoisomerase Inhibitors)
Mechanism of action
Binds to topoisomerase I to produce double-strand breaks in DNA
Common side effects
- Neutropenia
- Anemia
- Leukopenia
- Nausea
- Thrombocytopenia
- Elevated bilirubin
- Diarrhea
Known interactions (4)
- clozapine + irinotecan Contraindicated
- carbamazepine + irinotecan Major
- irinotecan + itraconazole Major
- chloramphenicol + irinotecan Moderate
Related conditions
Frequently asked questions
What drug class is irinotecan?
irinotecan belongs to: Oncology.
How does irinotecan work?
Binds to topoisomerase I to produce double-strand breaks in DNA
What are the common side effects of irinotecan?
Neutropenia, Anemia, Leukopenia, Nausea, Thrombocytopenia, Elevated bilirubin, Diarrhea
Which drugs interact with irinotecan?
clozapine, carbamazepine, itraconazole, chloramphenicol
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.