Drug reference
sofosbuvir-velpatasvir
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Anti Virals (Hepatits Viruses)
Mechanism of action
Sofosbuvir: Inhibitor of HCV NS5B RNA-dependent polymerase; its inhibition, in turn, suppresses viral replication Velpatasvir: Pangenotypic HCV NS5A inhibitor; the NS5A protein is required for viral replication
Common side effects
- Asthenia
- Insomnia
- Anemia
- Headache
- Fatigue
- Hemoglobin <10 g/dL
Contraindications
- Sofosbuvir/velpatasvir plus ribavirin combination regimen is contraindicated in patients for whom ribavirin is contraindicated
Known interactions (1)
- colchicine + sofosbuvir-velpatasvir Moderate
Related conditions
Frequently asked questions
What drug class is sofosbuvir-velpatasvir?
sofosbuvir-velpatasvir belongs to: Anti Virals.
How does sofosbuvir-velpatasvir work?
Sofosbuvir: Inhibitor of HCV NS5B RNA-dependent polymerase; its inhibition, in turn, suppresses viral replication Velpatasvir: Pangenotypic HCV NS5A inhibitor; the NS5A protein is required for viral replication
What are the common side effects of sofosbuvir-velpatasvir?
Asthenia, Insomnia, Anemia, Headache, Fatigue, Hemoglobin <10 g/dL
Which drugs interact with sofosbuvir-velpatasvir?
colchicine
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