Drug interactions
Aceclofenac + Glibenclamide
Severity: Moderate
Aceclofenac and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may potentiate the glucose-lowering effect of glyburide. Aceclofenac could therefore increase the risk of hypoglycemia, particularly in patients with renal impairment.
What this interaction means in plain words
Aceclofenac and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aceclofenac belongs to Musculoskeletal; Glibenclamide belongs to Endocrine.
Why it happens
Possible CYP2C9 competition and protein-binding displacement; not firmly established.
What to do
Monitor blood glucose when starting or stopping aceclofenac and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Aceclofenac
Frequently asked questions
Can I take Aceclofenac with Glibenclamide?
MediHelp rates the interaction as moderate. Aceclofenac and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may potentiate the glucose-lowering effect of glyburide. Aceclofenac could therefore increase the risk of hypoglycemia, particularly in patients with renal impairment.
How serious is the interaction between Aceclofenac and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping aceclofenac and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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