Drug interactions
Acemetacin + Glibenclamide
Severity: Moderate
Acemetacin and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as acemetacin can potentiate sulfonylureas and occasionally cause hypoglycemia. The effect is variable and generally modest.
What this interaction means in plain words
Acemetacin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible protein-binding displacement and reduced glyburide clearance; mechanism not firmly established.
What to do
Monitor blood glucose when starting or stopping the NSAID and reduce the glyburide dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Acemetacin with Glibenclamide?
MediHelp rates the interaction as moderate. Acemetacin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as acemetacin can potentiate sulfonylureas and occasionally cause hypoglycemia. The effect is variable and generally modest.
How serious is the interaction between Acemetacin and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the NSAID and reduce the glyburide dose if needed.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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