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Drug interactions

Acetazolamide + Diflunisal

Severity: Major

Acetazolamide and Diflunisal: major interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Acetazolamide and salicylates such as diflunisal can raise each other's levels, and acetazolamide can drive salicylate into the brain, causing neurotoxicity such as confusion, lethargy and tinnitus.

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