Drug reference
diflunisal
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Musculoskeletal (NSAIDs)
Mechanism of action
Inhibits cyclooxygenase-1 (COX-1) & (COX-2), thereby inhibiting prostaglandin synthesis, which is responsible for gastric mucosa production, and the inflammatory response respectively.
Common side effects
- Increased liver function test
- Indigestion
- Constipation
- Body fluid retention
- Abdominal pain
Contraindications
- Absolute: hypersensitivity to diflunisal, ASA allergy, history of aspirin triad, CABG Relative: bleeding disorders, duodenal/gastric/peptic ulcer, renal impairment, stomatitis, ulcerative colitis, upper GI dz, late pregnancy (risk of premature closure of ductus arteriosus)
Related conditions
Frequently asked questions
What drug class is diflunisal?
diflunisal belongs to: Musculoskeletal.
How does diflunisal work?
Inhibits cyclooxygenase-1 (COX-1) & (COX-2), thereby inhibiting prostaglandin synthesis, which is responsible for gastric mucosa production, and the inflammatory response respectively.
What are the common side effects of diflunisal?
Increased liver function test, Indigestion, Constipation, Body fluid retention, Abdominal pain
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