Drug interactions
Acetylsalicylic acid + Glibenclamide
Severity: Moderate
Acetylsalicylic acid and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose salicylates can enhance the glucose lowering of glyburide and cause hypoglycemia. Low-dose aspirin is unlikely to have a meaningful effect.
What this interaction means in plain words
Acetylsalicylic acid and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Glibenclamide belongs to Endocrine.
Why it happens
Salicylates have intrinsic glucose-lowering effects and may displace sulfonylureas from protein binding.
What to do
Monitor blood glucose when starting or stopping regular analgesic-dose aspirin and reduce the glyburide dose if hypoglycemia occurs. Educate the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Acetylsalicylic acid with Glibenclamide?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose salicylates can enhance the glucose lowering of glyburide and cause hypoglycemia. Low-dose aspirin is unlikely to have a meaningful effect.
How serious is the interaction between Acetylsalicylic acid and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping regular analgesic-dose aspirin and reduce the glyburide dose if hypoglycemia occurs. Educate the patient on hypoglycemia symptoms.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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