Drug interactions
Aescin + Glibenclamide
Severity: Minor
Aescin and Glibenclamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Horse chestnut has been suggested to have some glucose-lowering activity, which might add to glyburide. Evidence is minimal and the effect is uncertain.
What this interaction means in plain words
Aescin and Glibenclamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aescin belongs to Cardiovascular; Glibenclamide belongs to Endocrine.
Why it happens
Possible additive glucose-lowering effect; the mechanism is not established.
What to do
Monitor blood glucose when starting or stopping horse chestnut products and counsel on hypoglycemia symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aescin
- Aescin + Ketorolac Major
- Acemetacin + Aescin Moderate
- Aescin + Aspirin Moderate
- Aescin + Aspirin / citric acid / sodium bicarbonate Moderate
- Aescin + Aspirin rectal Moderate
- Aescin + Bemiparin Moderate
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Aescin with Glibenclamide?
MediHelp rates the interaction as minor. Aescin and Glibenclamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Horse chestnut has been suggested to have some glucose-lowering activity, which might add to glyburide. Evidence is minimal and the effect is uncertain.
How serious is the interaction between Aescin and Glibenclamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping horse chestnut products and counsel on hypoglycemia symptoms.
What other medicines interact with Aescin?
MediHelp also lists interactions of Aescin with, for example, Ketorolac, Acemetacin, Aspirin. The full list is on the Aescin page.
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