Drug interactions
Afatinib + Itraconazole
Severity: Moderate
Afatinib and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may modestly increase afatinib exposure, which can worsen diarrhea, rash and other adverse effects.
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to see why Afatinib and Itraconazole interact, what to do about it, and the sources.
- Mechanism of action
- Clinical management
- Evidence level
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Itraconazole
Other interactions of Afatinib
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.