Drug reference
itraconazole
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Anti Fungals (Azoles)
Mechanism of action
Triazole antifungal agent; inhibits cytochrome P450-dependent synthesis of ergosterol, which in turn inhibits cell-membrane formation
Common side effects
- Rash
- Vomiting
- Edema
- Headache
- Nausea
- Abnormal liver function test results
Contraindications
- Contraindicated with certain CYP3A4 substrate drugs (Black Box Warnings)
- Coadministration with colchicine, fesoterodine, and solifenacin in patients with varying degrees of renal or hepatic impairment
- Coadministration with eliglustat in patients who are poor or intermediated CYP2D6 metabolizers, or if coadministered with strong or moderate CYP2D6 inhibitors
- Increased plasma concentrations resulting from coadministration with itraconazole of some of the aforementioned drugs can lead to QT prolongation and ventricular tachyarrhythmias
- Treatment of onychomycosis in women who are pregnant or plan to become pregnant
Known interactions (26)
- alfuzosin + itraconazole Contraindicated
- avanafil + itraconazole Contraindicated
- dronedarone + itraconazole Contraindicated
- eletriptan + itraconazole Contraindicated
- eplerenone + itraconazole Contraindicated
- ergotamine + itraconazole Contraindicated
- felodipine + itraconazole Contraindicated
- flibanserin + itraconazole Contraindicated
- itraconazole + ivabradine Contraindicated
- itraconazole + lovastatin Contraindicated
- itraconazole + lurasidone Contraindicated
- itraconazole + midazolam Contraindicated
- itraconazole + pimozide Contraindicated
- itraconazole + quinidine Contraindicated
- itraconazole + ranolazine Contraindicated
- itraconazole + rifampin Contraindicated
- itraconazole + silodosin Contraindicated
- itraconazole + simvastatin Contraindicated
- itraconazole + ticagrelor Contraindicated
- itraconazole + tolvaptan Contraindicated
- colchicine + itraconazole Major
- irinotecan + itraconazole Major
- itraconazole + methadone Major
- itraconazole + solifenacin Major
- fesoterodine + itraconazole Moderate
- indapamide + itraconazole Moderate
Related conditions
Frequently asked questions
What drug class is itraconazole?
itraconazole belongs to: Anti Fungals.
How does itraconazole work?
Triazole antifungal agent; inhibits cytochrome P450-dependent synthesis of ergosterol, which in turn inhibits cell-membrane formation
What are the common side effects of itraconazole?
Rash, Vomiting, Edema, Headache, Nausea, Abnormal liver function test results
Which drugs interact with itraconazole?
alfuzosin, avanafil, dronedarone, eletriptan, eplerenone, ergotamine, felodipine, flibanserin, ivabradine, lovastatin, lurasidone, midazolam, pimozide, quinidine, ranolazine
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