Drug interactions
Afatinib + Ketoconazole
Severity: Moderate
Afatinib and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole inhibits P-glycoprotein and can modestly increase afatinib exposure, which may worsen diarrhea, rash and other adverse effects.
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Other interactions of Ketoconazole
Other interactions of Afatinib
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