Drug interactions
Albendazole + Metronidazole
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Potential additive hepatotoxicity; coadministration may increase the risk of elevated transaminases or clinically significant liver injury, particularly with prolonged albendazole therapy or underlying hepatic impairment.
Mechanism of action
Pharmacodynamic additive hepatotoxicity; no clinically significant pharmacokinetic interaction is established.
Clinical management
Obtain baseline liver function tests (LFTs) and monitor during coadministration and shortly after; avoid or use extreme caution in active or severe hepatic disease; counsel patients to report jaundice, dark urine, right upper quadrant pain, or unexplained fatigue; discontinue or modify therapy if clinically significant LFT elevations or hepatitis occur.
Drug reference
References
- Albenza (albendazole) Prescribing Information — Warnings and Precautions: Hepatic effects and monitoring — FDA Label
- Metronidazole Prescribing Information — Warnings: Hepatotoxicity, including in patients with Cockayne syndrome — FDA Label
- Albendazole + Metronidazole — Drug interaction monograph — Lexicomp
Frequently asked questions
Can I take Albendazole with Metronidazole?
The interaction is rated: Moderate. Potential additive hepatotoxicity; coadministration may increase the risk of elevated transaminases or clinically significant liver injury, particularly with prolonged albendazole therapy or underlying hepatic impairment.
How serious is the interaction between Albendazole and Metronidazole?
The interaction is rated: Moderate. Evidence level: Low.
How is the interaction between Albendazole and Metronidazole managed?
Obtain baseline liver function tests (LFTs) and monitor during coadministration and shortly after; avoid or use extreme caution in active or severe hepatic disease; counsel patients to report jaundice, dark urine, right upper quadrant pain, or unexplained fatigue; discontinue or modify therapy if clinically significant LFT elevations or hepatitis occur.
Why do Albendazole and Metronidazole interact?
Pharmacodynamic additive hepatotoxicity; no clinically significant pharmacokinetic interaction is established.
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