Drug interactions
Aliskiren + Hydrochlorothiazide-irbesartan
Severity: Contraindicated
Aliskiren and Hydrochlorothiazide-irbesartan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining aliskiren with an angiotensin receptor blocker produces dual renin-angiotensin system blockade, raising the risk of hypotension, hyperkalemia and acute kidney injury without outcome benefit.
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to see why Aliskiren and Hydrochlorothiazide-irbesartan interact, what to do about it, and the sources.
- Mechanism of action
- Clinical management
- Evidence level
Free 14-day trial. No card needed.
Other interactions of Hydrochlorothiazide-irbesartan
Other interactions of Aliskiren
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
