Drug interactions
Alogliptin + Glibenclamide
Severity: Moderate
Alogliptin and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Alogliptin has low intrinsic hypoglycemic risk but increases the risk when added to a sulfonylurea such as glyburide. Hypoglycemia may be significant, especially in older patients or those with renal impairment.
What this interaction means in plain words
Alogliptin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alogliptin belongs to Endocrine; Glibenclamide belongs to Endocrine.
Why it happens
Additive glucose-lowering effects via DPP-4 inhibition plus sulfonylurea-driven insulin release.
What to do
Consider lowering the glyburide dose when adding alogliptin and monitor blood glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Alogliptin
- Alogliptin + Amlodipine-benazepril Moderate
- Alogliptin + Benazepril Moderate
- Alogliptin + Captopril Moderate
- Alogliptin + Captopril-hydrochlorothiazide Moderate
- Alogliptin + Chlorpropamide Moderate
- Alogliptin + Dulaglutide Moderate
Frequently asked questions
Can I take Alogliptin with Glibenclamide?
MediHelp rates the interaction as moderate. Alogliptin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alogliptin has low intrinsic hypoglycemic risk but increases the risk when added to a sulfonylurea such as glyburide. Hypoglycemia may be significant, especially in older patients or those with renal impairment.
How serious is the interaction between Alogliptin and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the glyburide dose when adding alogliptin and monitor blood glucose.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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