Drug interactions
Alogliptin-pioglitazone + Glibenclamide
Severity: Moderate
Alogliptin-pioglitazone and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding alogliptin and pioglitazone to glyburide increases the risk of hypoglycemia, which may be prolonged with glyburide, especially in older adults or renal impairment.
What this interaction means in plain words
Alogliptin-pioglitazone and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alogliptin-pioglitazone belongs to Endocrine; Glibenclamide belongs to Endocrine.
Why it happens
Additive glucose-lowering effects from insulin secretagogue action, DPP-4 inhibition and insulin sensitization.
What to do
Consider reducing the glyburide dose when starting the combination. Monitor blood glucose and counsel on hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alogliptin-pioglitazone
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Alogliptin-pioglitazone with Glibenclamide?
MediHelp rates the interaction as moderate. Alogliptin-pioglitazone and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding alogliptin and pioglitazone to glyburide increases the risk of hypoglycemia, which may be prolonged with glyburide, especially in older adults or renal impairment.
How serious is the interaction between Alogliptin-pioglitazone and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glyburide dose when starting the combination. Monitor blood glucose and counsel on hypoglycemia.
What other medicines interact with Alogliptin-pioglitazone?
MediHelp also lists interactions of Alogliptin-pioglitazone with, for example, Gemfibrozil, Insulin aspart, Insulin degludec. The full list is on the Alogliptin-pioglitazone page.
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