Drug interactions
Alprazolam + Lopinavir
Severity: Major
Alprazolam and Lopinavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted lopinavir inhibits CYP3A4 and can markedly increase alprazolam exposure, risking prolonged sedation and respiratory depression.
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Other interactions of Alprazolam
Other interactions of Lopinavir
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