Drug interactions
Alteplase + Defibrotide
Severity: Contraindicated
Alteplase and Defibrotide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Defibrotide has profibrinolytic activity, and combining it with the thrombolytic alteplase increases the chance of serious bleeding.
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to see why Alteplase and Defibrotide interact, what to do about it, and the sources.
- Mechanism of action
- Clinical management
- Evidence level
Free 14-day trial. No card needed.
Other interactions of Alteplase
Other interactions of Defibrotide
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
