Drug reference
alteplase
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Fibrinolytics)
Mechanism of action
Recombinant human tissue-type plasminogen activator (t-PA); produces local fibrinolysis Promotes thrombolysis by converting plasminogen to plasmin; plasmin degrades fibrin and fibrinogen
Common side effects
- Stroke
- Pulmonary edema
- Accelerated idioventricular rhythm
- Arterial embolism
- Bruising
Contraindications
- Do not administer to treat acute ischemic stroke in the following situations in which the risk of bleeding is greater than the potential benefit
- Significant closed head or facial trauma with radiographic evidence of brain injury or facial trauma within 3 months
- Do not administer for treatment of AMI or PE in the following situations in which the risk of bleeding is greater than the potential benefit
Related conditions
Frequently asked questions
What drug class is alteplase?
alteplase belongs to: Cardiovascular.
How does alteplase work?
Recombinant human tissue-type plasminogen activator (t-PA); produces local fibrinolysis Promotes thrombolysis by converting plasminogen to plasmin; plasmin degrades fibrin and fibrinogen
What are the common side effects of alteplase?
Stroke, Pulmonary edema, Accelerated idioventricular rhythm, Arterial embolism, Bruising
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